Certainty
Established
Strong Evidence
Multiple high-quality randomised controlled trials (RCTs) or systematic reviews with consistent findings. The body of evidence is large enough that conclusions are unlikely to change with new research.
Examples
- Acupuncture for chronic low-back pain
- Mindfulness-Based Stress Reduction for anxiety
- St John's Wort for mild-to-moderate depression
What this means
You can have reasonable confidence that this approach has demonstrated measurable effects in controlled conditions. It does not mean it works for every person or every condition.