Persistent Tiredness
A sustained sense of physical and mental weariness that differs from ordinary tiredness by its persistence, resistance to rest, and ongoing interference with daily life.
Quick answer
Persistent tiredness (ICD-10: R53; ICD-11: MG22) is among the most common primary care presentations. Reversible causes include thyroid dysfunction, anaemia, and nutritional deficiency. Aerobic exercise and sleep optimisation have strong evidence. Post-exertional worsening indicates possible ME/CFS requiring pacing.
Recognition
Do any of these feel familiar?
Constant feeling of being worn out regardless of sleep
Low motivation and difficulty initiating tasks
Cognitive heaviness and slowed mental processing
Need for more rest than would normally be required
Tiredness that does not lift after a night of sleep
What is Persistent Tiredness?
A sustained sense of physical and mental weariness that differs from ordinary tiredness by its persistence, resistance to rest, and ongoing interference with daily life.
Approaches Commonly Explored
Commonly explored for conditions related to Persistent Tiredness, grouped by mechanism — select your subtype above to highlight the most relevant path.
How to use these approaches
Most people begin with Stabilise approaches, then progress toward Resolve and Sustain.
Energy production, nutrient metabolism, and cellular function.
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