What it is
Agitation spans anxiety disorders, akathisia, bipolar disorder, and delirium.
A state of inner unease, physical restlessness, or psychological distress characterised by heightened emotional reactivity and an inability to find calm. Distinct from anxiety by its greater emphasis on outward agitation.

At a glance
What it is
Agitation spans anxiety disorders, akathisia, bipolar disorder, and delirium.
Commonly experienced as
Evidence context
Emerging evidenceSafety
See staying safeHistory & Origin
Agitation combines inner psychological tension with physical restlessness — a driven, unable-to-settle quality that differs from simple anxiety in its more pronounced physical expression. It manifests as pacing, an inability to stay in one position, and heightened reactivity to stimuli. Agitation features in anxiety disorders, bipolar disorder (particularly mixed or manic states), acute stress responses, substance withdrawal, certain medications, thyroid dysfunction, pain states, and dementia in older adults. Distinguishing the context is important — acute psychiatric agitation requires different management from stress-driven or hormonal agitation.
The Evidence
What research and clinical practice say about agitation — its causes, contexts, and approaches to support.
Agitation is well-recognised but context-dependent
Agitation appears across psychiatric, medical, and neurological conditions, and its management depends heavily on identifying the underlying cause. Evidence supports both psychological and pharmacological approaches, with cause-specific assessment being essential.
Agitation combined with confusion or fever may indicate delirium, which requires urgent medical review. Agitation escalating toward risk of harm to self or others warrants immediate support. In older adults, new or worsening agitation — particularly in dementia — should prompt a medication and health review rather than behavioural management alone.
Agitation features in anxiety disorders, bipolar disorder, PTSD, substance withdrawal, thyroid dysfunction, pain, and medication side effects. Akathisia — a distressing inner restlessness caused by certain medications — is frequently misattributed to psychiatric deterioration. Identifying the context is a clinical priority before any intervention is considered.
Dialectical Behaviour Therapy (DBT) has evidence for agitation linked to emotion dysregulation. Pharmacological approaches are used in acute psychiatric and delirium-related agitation, with cause-specific treatment being the priority. Evidence for complementary approaches is more limited and generally studied as adjuncts rather than standalone options.
Sedating an agitated person without identifying and addressing the underlying cause can mask serious conditions, particularly delirium. Stimulant substances or supplements are not appropriate for those with established agitation patterns. If agitation is new, worsening, or accompanied by other symptoms, professional assessment should come before any self-directed approach.
Psychological therapies, lifestyle regulation, and stress-reduction practices are commonly used for agitation linked to anxiety or emotional dysregulation. Traditional systems such as TCM and Ayurveda offer calming and grounding approaches, though evidence for these specifically in agitation is limited. Any approach is best considered alongside professional assessment to rule out medical or medication-related causes.
A GP or mental health professional can help identify whether agitation is linked to a psychiatric condition, medication, or underlying health issue. If agitation is sudden in onset, accompanied by confusion, or escalating in intensity, seek assessment promptly. Self-directed tools and complementary approaches are not a substitute for professional evaluation when the cause is unclear.
Safety first
General, informational guidance — not diagnostic. A qualified practitioner can advise on your own situation.
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References
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