What it is
Forceful expulsion of stomach contents through the mouth — a protective reflex with many possible underlying causes.
Forceful expulsion of stomach contents through the mouth — a protective reflex with many possible underlying causes.

At a glance
What it is
Forceful expulsion of stomach contents through the mouth — a protective reflex with many possible underlying causes.
Commonly experienced as
Evidence context
Research-supportedSee the evidence snapshotContext
Vomiting is the forceful, involuntary expulsion of gastric contents through the mouth — coordinated by the vomiting centre in the brainstem in response to signals from the gastrointestinal tract, vestibular system, chemoreceptor trigger zone, and cerebral cortex. It is a protective reflex (expelling ingested toxins) but also occurs as a symptom of many conditions without a toxin to expel. Common causes include gastroenteritis (viral or bacterial), food poisoning, motion sickness, pregnancy (particularly the first trimester), migraine, medication side effects (particularly opioids, cytotoxics, antibiotics), raised intracranial pressure, acute appendicitis, and bowel obstruction. Persistent vomiting risks dehydration, electrolyte imbalance, and in severe cases Mallory-Weiss oesophageal tears. Blood in vomit requires immediate assessment.
The Evidence
What research and clinical practice tell us about vomiting — its causes, management options, and when to seek urgent care.
Vomiting is well-studied with clear clinical guidance
Vomiting has a well-understood physiology and a strong evidence base for management across multiple causes. Identifying the underlying cause is essential, as treatment approaches and urgency vary considerably.
Seek urgent care if vomit contains blood, if vomiting is accompanied by severe abdominal pain or rigidity, or if you cannot keep any fluids down. Unintentional weight loss alongside persistent digestive symptoms also warrants prompt professional evaluation. These signs may indicate conditions requiring urgent intervention.
Ondansetron has very strong evidence for controlling chemotherapy-related vomiting. Metoclopramide has strong evidence for vomiting related to delayed gastric emptying. For pregnancy-related nausea and vomiting, ginger has moderate supporting evidence. Evidence quality varies by cause, so management should be matched to the underlying trigger.
Common causes include viral gastroenteritis, food poisoning, motion sickness, migraine, medication side effects, and early pregnancy. Less commonly, raised intracranial pressure or bowel obstruction may be responsible. Persistent vomiting risks dehydration and electrolyte imbalance, making fluid replacement an important early consideration.
Mild, short-lived vomiting often responds to rest, small sips of fluid, and bland food when tolerated. Antiemetic medications may be appropriate for moderate or persistent cases and should be discussed with a qualified practitioner. Complementary approaches such as ginger or acupressure have some supporting evidence for nausea, though evidence for vomiting specifically is more limited.
If vomiting lasts more than 24–48 hours, recurs frequently, or is accompanied by other concerning symptoms, a qualified health professional should assess the underlying cause. Self-management is not a substitute for professional assessment when symptoms are severe, prolonged, or unexplained. Early assessment can prevent complications such as dehydration.
Evidence for complementary approaches is generally stronger for nausea than for vomiting itself. Many studies focus on specific populations such as pregnant individuals or chemotherapy patients, so findings may not apply universally. Vomiting is a symptom, not a standalone condition — managing it without identifying the cause may delay appropriate care.
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